Recombinant human CNOT8 protein
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| 基因名 | CNOT8 |
|---|---|
| 英文全称 | CCR4-NOT transcription complex, subunit 8 |
| 别称 | CAF1;CALIF;Caf1b;POP2;hCAF1 |
| 中文名称 | CCR4-NOT转录复合物,亚基8 |
| Uniprot | Q9UFF9 |
| GeneID | 9337 |
| 交叉反应(推测) | Human Mouse |
| 氨基酸大小 | 34kDa |
| 表达氨基酸 | 1-292aa |
| Background | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate.Its function seems to be partially redundant with that of CNOT7.Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation.Additional complex functions may be a consequence of its influence on mRNA expression.Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| Endotoxin | / |
| Bioactive | Not tested. |
| Tag information | With a 6His tag at the N-terminus. |
| 单位 | 支 |
| 规格 | 10ug50ug100ug1mg |
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